Pipeline

  • Preclinical
    Animal Pharmacology Testing
  • GLP Toxicology
  • Phase I
    Dose Escalation
  • Phase II
  • Phase III

INT230-6 (collaboration)

Colorectal Non-MSI High

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Merck’s Keytruda (non-immunogenic “cold tumors”)

Sarcoma

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ BMS’ Yervoy (immunogenic cold)

Bile Duct

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Keytruda (cold)

Pancreatic

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Keytruda (cold)

Squamous Cell

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Keytruda (patients who failed PD-1)

Breast

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Yervoy

Liver

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
+ Yervoy

INT230-6 mTNBC

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
Fast Track Monotherapy

INT230-6 BC
pre-surgery

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III
Monotherapy Pre-surgical Setting (local or regional disease)

INT33X
(Next Generation)

  • Preclin
  • GLP Toxicology
  • Phase I
  • Phase II
  • Phase III

mTNBC = metastatic Triple Negative Breast Cancer
BC = Breast Cancer