Treat Cancer at Any Stage

A Bold, Novel Drug Approach to Kill Tumors and Activate Immune Response

Treat locally, act globally. Intensity is developing proprietary intratumoral immunotherapy products that both directly kill injected solid tumors AND induce immune system recognition of cancer cells throughout the body to address the three challenges of cancer treatment: local, regional, and metastatic disease.

A Bold, Novel Drug Approach to Kill Tumors and Activate Immune Response to Treat Cancer at Any Stage

Treat locally, act globally. Intensity is developing proprietary intratumoral immunotherapy products that both directly kill injected solid tumors AND induce immune system recognition of cancer cells throughout the body to address the three challenges of cancer treatment: local, regional, and metastatic disease.

Tumor
Injection

DfuseRx℠ is our novel proprietary penetration enhancer platform technology that enables therapeutic agents to be injected directly into solid tumors for improved absorption.

Diffusion
Through Tumor

Once injected, DfuseRx enables the injected drug solution to disperse throughout the tumor and increases the drug’s diffusion into cancer cells.

Localized
Cell Death

The absorbed active agents in the injected tumor induce cancer cell death, without disruption of the cell membrane, in a manner that results in an influx of immune cells throughout the tumor.

System-wide
Immune Response

Tumor cell death exposes the immune system to antigens of the patient’s own cancer, inducing a personalized CD4+ and CD8+ T cell response, attacking the site of the former tumor while attacking distal cancer sites.

Increased
Survival

Exploratory analysis of data from a Phase 1/2 trial of relapsed and refractory solid tumor patients with a variety of cancers indicates an association between percent of tumor burden treated and survival.

Technology and Clinical Data

DfuseRxSM is our novel proprietary product discovery technology that enables drug compounds including cytotoxic agents to be injected directly into solid tumors with high absorption. The technology makes use of novel dispersion and cell penetration enhancer molecules that we have identified.
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I mourn the passing of my friend, Fred Frank - a true gentleman. In Fred's presence everyone was special even entry level staff, which I was when we first met. Heart felt condolences to Mary and Frederick. Lewis H. Bender CEO

It’s an honor to be named June’s “Innovator of the Month” by Sen. Murphy. We are proud to be recognized for our efforts and to represent Connecticut’s emerging biotech sector. A huge thank you to our amazing staff at Westport!

Read more: https://bit.ly/3jwwjqz

@ChrisMurphyCT

Yesterday, our CEO, Lew Bender, participated in a fireside chat titled, “Unprecedented Improvement Upon Intratumoral Injection” at the Virtual Healthcare Private Company Forum hosted by Roth Capital.

Learn more: https://bit.ly/3qIpB2F

#RothConference #InvestorConference

These strongly encouraging results in our two @ASCO presentations provide further support of INT230-6’s potential in directly killing tumors and shrinking them through abscopal effects.

#ASCO21

Use of INT230-6 alone or in combination with ipilimumab showed a median overall survival of 23.6 months in advanced sarcoma/chordoma patients compared to an expected survival of only 4 to 8 months for these patients in phase 1/2 studies.

#ASCO21

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