New Treatment Concept
In 2016, nearly 600,000 Americans died of cancer. Cancer is the second most common cause of death in the US after heart disease. Compared to the economic impact of premature death and disability of all causes of death, cancer has the greatest cost worldwide.
Cancer originates from a person’s own cells and their immune system usually is not able to recognize the cancer. As a result, tumors can begin to grow uncontrollably. Late stage cancer consists of large well-defined tumors and small unseen groups of cells or micro-metastases that have been shed from the tumors. These metastases can exist either in the blood or body tissue. Cancer is thus both a regional and a systemic disease. To be effective a treatment must destroy both the existing tumors as well as the unseen micrometastases. However, tumors often thwart the immune system using a variety of processes. The great challenge today is to find a treatment method that can effectively defeat both the large tumors as well as track down and kill the unseen micrometastases.
Most drug therapies are systemic given via oral or intravenous (IV) administration. Unfortunately, in later disease these therapies have only a small effect on outcomes for the majority of cancer patients (Morgan (Clinical Oncology (R Coll Radiol) 2004 Dec;16(8):549-60). The lack of therapeutic efficacy for systemically administered drugs may be due in large part to the low levels of drug reaching the tumor sites. In addition, once at the tumor there is often poor mass transfer of the drug into the cancer cells. This results in drug concentrations that most often are insufficient for destruction of the large visible tumors.
Even with good treatment outcomes, whether surgical, chemical, radiation or ablation methods, these techniques remain invasive, have severe side effects that damage the body and are demanding on the patient. The reality today is that if cancer is detected late, most treatments are highly toxic and few provide patients with much hope of long term survival.
Cancer cells need to absorb nutrients at a high rate. As a result, cancer cell membranes are more fluid than those of normal tissue. Our technology improves diffusion of potent agents directly into cells to kill tumors. The result is also the presentation of personalized antigen to the immune system stimulating a systemic anti-cancer attack.Back to Technology